Episode 1 of the new season of Elimination Exchange, Global Health at a Crossroads, host, Simon Bland, CEO of GLIDE, in discussion with Sir Professor Peter Piot, Director and Handa Professor of Global Health at the London School of Hygiene and Tropical Medicine and Fellow of the Academy of Medical Sciences, as they explore how current challenges are forcing a radical rethink of global health structures, emphasizing country ownership, the power of innovation, and the shift from ‘donor-recipient’ to true partnership.